Pertactin-Negative Bordetella pertussis Strains: Evidence for a Possible Selective Advantage
نویسندگان
چکیده
منابع مشابه
Pertactin-negative Bordetella pertussis strains: evidence for a possible selective advantage.
BACKGROUND A recent increase in Bordetella pertussis without the pertactin protein, an acellular vaccine immunogen, has been reported in the United States. Determining whether pertactin-deficient (PRN(-)) B. pertussis is evading vaccine-induced immunity or altering the severity of illness is needed. METHODS We retrospectively assessed for associations between pertactin production and both cli...
متن کاملVirulence of Pertactin-Negative Bordetella pertussis Isolates from Infants, France
Bordetella pertussis isolates that do not express pertactin (PRN) are increasing in regions where acellular pertussis vaccines have been used for >7 years. We analyzed data from France and compared clinical symptoms among infants <6 months old infected by PRN-positive or PRN-negative isolates. No major clinical differences were found between the 2 groups.
متن کاملBordetella pertussis Strain Lacking Pertactin and Pertussis Toxin.
A Bordetella pertussis strain lacking 2 acellular vaccine immunogens, pertussis toxin and pertactin, was isolated from an unvaccinated infant in New York State in 2013. Comparison with a French strain that was pertussis toxin-deficient, pertactin wild-type showed that the strains carry the same 28-kb deletion in similar genomes.
متن کاملSimple Algorithm for Identification of Bordetella pertussis Pertactin Gene Variants.
Studies performed in several countries have demonstrated the recent emergence and subsequent dominance of circulating Bordetella pertussis strains harboring pertactin and pertussis toxin variants not included in pertussis vaccines. Determination of the pertactin gene variants is commonly performed using a time-consuming and expensive sequence analysis. We developed a simple and reliable pertact...
متن کاملSignificant Decrease in Pertactin-Deficient Bordetella pertussis Isolates, Japan
Prevalence of pertactin-lacking Bordetella pertussis isolates has been observed worldwide. In Japan, however, we found that the frequency of pertactin-deficient isolates in 2014-2016 (8%) was significantly lower than the frequency in 2005-2007 (41%), 2008-2010 (35%), and 2011-2013 (25%). This reduction was closely associated with changes in genotypes.
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ژورنال
عنوان ژورنال: Clinical Infectious Diseases
سال: 2014
ISSN: 1058-4838,1537-6591
DOI: 10.1093/cid/ciu788